An expression signature of four highly expressed genes (KRT6A, CEACAM7, S100A7 and SPRR3) in normal cervical epithelium was identified and confirmed, and three abundantly expressed genes (ANXA2, GJA1 and LGALS7) were found to have altered expression in CIN III. The gene discussed is S100A7; the disease is uterine cervix carcinoma in situ.