Tumour expression of p16/p14ARF mRNA was heterogeneous (Figure 3B) and although there was no correlation between expression and CDKN2A copy number (P=0.35; ANOVA with t-test), homozygous deletion of the CDKN2A gene (samples 07/01, 27/02, 04/03 and 36/05) resulted in loss of p16/p14ARF mRNA expression. The gene discussed is CDKN2A; the disease is neoplasm.