Before and after adjustment for these covariates (BMI, level of physical activity, history of diabetes mellitus and regular multivitamin use), IGF-I, IGFBP-3, the IGF-I : IGFBP-3 molar ratio, and IGF-II were not associated with risk of pancreatic cancer (Table 2). Here, IGFBP3 is linked to familial pancreatic carcinoma.