The HRs for OS from NSCLC associated with MTHFS Thr202Ala heterozygosity, homozygosity and carrier status were 1.4 (95% CI: 1.02–1.92), 1.45 (95% CI: 0.44–4.71) and 1.4 (95% CI: 1.06–1.91), respectively. The gene discussed is MTHFS; the disease is non-small cell lung carcinoma.