TNFRSF11B and Ewing sarcoma: Bisphosphonates are known to inhibit osteoclast formation and resorption activity and to induce osteoclast apoptosis (Rogers et al, 2000); bisphosphonates have also been shown to inhibit the growth of Ewing's sarcomas through mechanisms that involve upregulation of osteoprotegerin (Zhou et al, 2005).