Among these candidate cytokines, IL-6, which activates Stat3 through the glycoprotein 130/Janus kinase (gp130/Jak) pathway, is notable for its pleiotropic tumor-promoting activities, including anti-apoptotic, pro-invasive, and immune-stimulatory effects attributable to the activation of Stat3 target genes [26,27]. This evidence concerns the gene STAT3 and neoplasm.