As CFS patients and adult patients with a growth hormone (GH) deficiency report similar symptoms such as fatigue, myalgia, a diminished sense of well-being, and reduced physical capacity [4,5] and treatment of GH-deficient adults with GH has measurable effects on physical function and perception of fatigue [6], GH status is a focus of this research.. This evidence concerns the gene GH1 and myalgic encephalomeyelitis/chronic fatigue syndrome.