CYP3A5 and Hypertension: For example, there are indications of positive derived-allele selection in the AGT gene for angiotensinogen [39] and CYP3A5 gene for cytochrome P450 [40] protecting against hypertension, and similarly positive derived-allele selection in the CAPN10 gene for calpain 10 [41] and PPARgamma gene [42]–[44] protecting against type-II diabetes.