VEGFA and non-small cell lung carcinoma: The anti-VEGF antibody is currently approved in combination with intravenous 5-fluorouracil (5-FU)-based chemotherapy, which typically is a combination of irinotecan, 5-FU, and leucovorin (IFL), for first- or second-line treatment of metastatic carcinoma of the colon or rectum (Hurwitz et al, 2004; Hurwitz and Saini, 2006) and, in conjunction with paclitaxel and carboplatin, for first-line treatment of unresectable, locally advanced, recurrent or metastatic nonsquamous, non-small cell lung cancer (NSCLC) (Sandler et al, 2006).