Sorafenib is an oral, small molecule inhibitor of multiple tyrosine kinase receptors involved both in angiogenesis and tumour cell proliferation: VEGFR-2, VEGFR-3, PDGFR-β, RAF kinase, FLT3, KIT, p38 MAP kinase (p38-alpha, MAPK14). Here, MAPK14 is linked to neoplasm.