ZDHHC9 and villous adenoma: Remarkably, upregulation of the DHHC9 protein was also detected in early lesions such as benign hyperplasic polyps and tubular and tubulo-villous adenomas (data not shown), as well as at premalignant sites in the colon mucosa (Figure 2B and Supplementary Figure 3N and O) These sites were either located adjacent to, or in close proximity to, adenocarcinomas, for example, detected at the transformation site (Supplementary Figure 3Q).