The smallest deletion, in subject 447, encompassed coding sequences of only four genes: PLCXD1, GTPBP6, PPP2R3B, and SHOX. This subject, who was ascertained on the basis of dyschondrosteosis, had a TSCS score of 43.6. The gene discussed is PLCXD1; the disease is Leri-Weill dyschondrosteosis.