At wk 10, xanthine dehydrogenase (Xdh), Max dimerization protein (Mad), protein kinase, cAMP dependent, catalytic, beta (Prkacb), plexin A2 (Plxna2), and 4.5 LIM domains 1 (Fhl1) in the DSS alone and AOM/DSS groups significantly suppressed their expression in comparison with the AOM alone group. The gene discussed is XDH; the disease is infectious otitis media.