At wk 5 or 10, tumor necrosis factor receptor superfamily, member 1b (Tnfrsf1b), interferon gamma inducible protein 47 (Ifi47), tumor necrosis factor, alpha-induced protein 9 (Tnfaip9), interferon gamma induced GTPase (Igtp), chemokine (C-C motif) receptor 1 (Ccr1), prostaglandin D2 synthase 2, hematopoietic (Ptgds2), transforming growth factor, beta 1 (Tgfb1), and toll-like receptor 2 (Tlr2) were up-regulated by > 2-fold in the AOM/DSS group compared to the untreated controls. This evidence concerns the gene TLR2 and infectious otitis media.