REN and Cirrhosis: Theory of peripheral arterial vasodilatation, proposed by Schrier et al. in 1988,21 in which cirrhosis and portal hypertension would cause progressive arterial vasodilatation, especially at splanchnic level, thus causing reduction of the effective volemia and subsequent activation of compensatory constrictive factors, such as the renin-angiotensin-aldosterone system, central nervous system, and antidiuretic hormone.