Diabetes mellitus is a chronic systemic disease, related to an absolute or relative insulin deficiency, manifested by a deficient insulin secretion by the pancreas and/or a deficient insulin action on the target tissue2 and, according to Kuzuya3, insulin action deficiency causes chronic hyperglycemia, leading to characteristic abnormalities in the metabolism of carbohydrates, lipids, proteins and others. Here, INS is linked to diabetes mellitus.