INS and Hyperglycemia: Diabetes mellitus is a chronic systemic disease, related to an absolute or relative insulin deficiency, manifested by a deficient insulin secretion by the pancreas and/or a deficient insulin action on the target tissue2 and, according to Kuzuya3, insulin action deficiency causes chronic hyperglycemia, leading to characteristic abnormalities in the metabolism of carbohydrates, lipids, proteins and others.