Metalloproteinase 2 (MMP2) or Gelatinase A or 72 Kda collagenase is a protein induced in the cell nucleus and is related to properties such as tumor progression - including growth, invasion, metastasis and angiogenesis (blood vessel growth), agreeing with Sun and Hemler16 (2001), who recognized the extracellular interactions of the MMP2, acting as proteolytic enzymes capable of degrading tissue connective components. This evidence concerns the gene MMP2 and neoplasm.