In vitro, VPA has been shown to inhibit proliferation in acute myeloid leukaemia cells expressing P-glycoprotein (P-gp) and MDR-associated protein 1 (Tang et al, 2004), and to increase sensitivity towards apoptosis in hepatoma cells resistant to epirubicin (Schuchmann et al, 2006). This evidence concerns the gene PGP and acute myeloid leukemia.