Gli-1 is known to induce expression of proliferative genes such as cyclin D2 (Yoon et al, 2002), FOXM1 and the ras-ERK pathway (Xie et al, 2001; Teh et al, 2002) and to reduce expression of cell cycle repressor p21/CIP1 in gastric carcinoma cell lines (Ohta et al, 2005). This evidence concerns the gene GLI1 and gastric carcinoma.