We have shown in this study that one mechanism may be via the activation of NF-κB and its transcriptional target, IL-8 (Aihara et al, 1997; Chu et al, 2003), in infiltrating inflammatory cells surrounding the lesions, as IL-8 was shown to induce Shh gene expression in gastric adenocarcinoma cells. This evidence concerns the gene SHH and gastric adenocarcinoma.