Table 2 shows the differences in angiogenesis parameters and hypoxia-related parameters between both sub-populations. High-grade CC-RCC had higher ECP% (Figure 2), higher TCP%, larger vessel area and higher VEGF protein expression. In contrast, MVD, CAIX protein expression and HIF-1α protein expression were lower in high-grade tumours. The gene discussed is VEGFA; the disease is renal cell carcinoma.