Mutations in the ACTA1 gene, more commonly associated with nemaline myopathy, have been recently implicated in an autosomal dominant myopathy with both central and minicores [22]; however, some patients in this pedigree had an associated cardiomyopathy, which is not a feature in RYR1-related CCD. The gene discussed is ACTA1; the disease is nemaline myopathy.