Many genes that showed higher relative expression in carcinomas with a TP53 mutation were involved in the cell cycle and cell proliferation (for example, CCNB2, CDCA5, CENPA, and UBE2C), while the genes with lower relative expression showed more diverse functions and were highly associated with ER status (for example, IRS1, ESR1, DNAL1 and NAT1). The gene discussed is IRS1; the disease is carcinoma.