BDNF and Anxiety: In contrast, the same study revealed increased anxietyon trial 2 in BDNF-treated rats, suggesting that different typesof anxiety may differently interplay with BDNF-modulated memories.In line with this, increased BDNF signaling in miceover-expressing trkB produced anxiolysis [165], while stress and anxiety correlate with memory deficits and reduction in brainBDNF [174, 175].