BDNF and Anxiety: Indeed, BDNF is a keyneurotrophic factor, acting through trkB receptor to regulatebrain growth, differentiation, and functioning [32, 160, 173].While an early study showed no anxiety or memory effects of BDNFgenetic ablation in mice, numerous other data did reveal suchactions (see Table 3 for details), also implying BDNFrole in aversive memories [158, 162].