In contrast, mutant mice with reduced sensitivity of thyroid receptors [60] display increased anxiety but reduced memory (Table 1), demonstrating that not always variousmanipulations exert synergetic effects on these two processes.Interestingly, while CRF has been traditionally linked to memoryand anxiety, nonanxiogenic doses of CRF type 1 and 2 receptoragonist urocortin produced anxiety (accompanied by amygdalarhyperexcitability) after 5 daily intra-amygdalar infusions in rats[168]. The gene discussed is CRH; the disease is Anxiety.