Several genes encoding protein products that are important in cancer and have functions related to cell cycle, growth, DNA replication and protein translation (such as CCND1, TOP2A, TOPBP1, TFRC; three members of H4 histone family [HIST1H4C, HIST1H4B, and HIST1H4E]; and EIF4G1). The gene discussed is TOPBP1; the disease is cancer.