Increased prevalence of STAT3 and EGR1 binding motifs were predicted in the promoters and distributed throughout the gene clusters over-expressed by UM-SCC cells, when compared with those in vertebrate promoters, indicating that these transcription factors could play a broader or co-regulatory role with other transcription factors in gene expression in HNSCC tumorigenesis [31-33,36]. This evidence concerns the gene STAT3 and head and neck squamous cell carcinoma.