Rats treated with diethylnitrosamine, an agent inducing chemical cirrhosis, show progressive liver fibrosis accompanied by increased expression ofVEGF and VEGF-receptor and active angiogenesis [1] Similarly, Yoshiji et al., using an experimental model of chemical inductionof hepatic cirrhosis, associated the development of liver fibrosiswith a significant increase of VEGF mRNA expression in the liver[7]. The gene discussed is VEGFA; the disease is Cirrhosis.