Previous studies have describedthe expression pattern of the different cytokines/chemokines,which involved in Th1 and/or Th2 polarization, in tissues,cultured cells, and serum from patients with OLP, including IL-2[9–11], IFN-alpha [11–14], TNF-alpha [9, 11, 12, 15–18], IL-4 [9, 12, 18], IL-6 [11, 13, 18, 19], IL-10 [9, 12, 18], and TGF-alpha [9, 12, 20], IL-1 [18], IL-8 [21, 22]. The gene discussed is TNF; the disease is oral lichen planus.