The level of TNF-alpha, IL-1-alpha, IL-6and IL-8 in TT of OLP patients and normal controls was determined.Our results showed that the concentration of TNF-alpha,IL-1-alpha, IL-6, and IL-8 was significantly higher in TT of OLPpatients than in that of controls, furthermore all ratios ofcytokines, TNF-alpha/IL-6, IL-1/IL-6, and IL-8/IL-6 in OLPpatients were decreased significantly, compared withthat of controls. Here, CXCL8 is linked to oral lichen planus.