By the age of 16 weeks, the C57BL/KsJ strain of db/db micedemonstrates a number of characteristics of progressed type 2diabetes and pancreatic β-cell dysfunction; compared to6-week old animals, serum insulin levels are nearly 10-fold lowerand serum glucose levels and glycohemoglobin are nearly doubled.Serum glucose, glycohemoglobin, and fibrinogen, commonly elevatedin insulin resistance, were reduced similarly by ROSI and LG268,and insulin content in pancreatic islets increased significantlywith both compounds. Here, INS is linked to type 2 diabetes mellitus.