The total fold change in STAT1-pY701 staining in IFN-α and IFN-β, but not IFN-γ, in stimulated versus unstimulated cells was systematically lower in CD8 (healthy [H], 2.76×; melanoma [M], 1.84×) and CD4 T cell (H, 3.32×; M, 2.9×) subsets and in the lymphocyte population as a whole (H, 2.84×; M, 1.81×) (Figure 3A–3C), supporting the results demonstrating reduced response of lymphocytes to type I IFNs. This evidence concerns the gene IFNA2 and melanoma.