In a study recently completed, “Salt Reduction to Avoid Hypertension” (SARAH), we found that salt sensitivity defined as the difference between blood pressure after four weeks of high (150 mmol daily) and four weeks of low (50 mmol daily) salt intake, i.e. a more clinically relevant intervention, was directly correlated to Nt-proANP and inversely correlated to plasma concentration of renin (P-renin) [11]. This evidence concerns the gene REN and Hypertension.