In one of the monogenic forms of hypertension, Liddle's syndrome, activating ENaC mutations affect the PY motif of ENaC with the consequence that ENaC becomes insensitive to down regulation by a protein coded by the Neural precursor cell Expressed Developmentally Down-regulated 4 Like (NEDD4L) gene [16], [17]. The gene discussed is NEDD4L; the disease is Liddle syndrome.