Interestingly, a similar correlation has been proposed for apoptosis induction by RES in MCF-7 breast cancer cells, in which inhibition of PI3K resulted in lower PKB/AKT activity, NF-κB inhibition and Bcl-2 downregulation (Pozo-Guisado et al, 2004; Pozo-Guisado et al, 2005). Here, AKT1 is linked to breast cancer.