In ICEU-treated tumours, there was a decrease in the Plp1 membrane precursors detected (i.e. phosphocholine and phosphoethanolamine), suggesting that ICEU causes a reduction in cell membrane turnover and cell proliferation, thus leading to the decrease of Plp 2 membrane degradation products (GPC and GPE) simultaneously to tumour growth inhibition (Lindskog et al, 2004; Valonen et al, 2005). The gene discussed is PLP1; the disease is neoplasm.