The most prominent changes in ICEU-treated tumour samples were observed from signals acquired by 1H 2D COSY spectra (Figure 6C) that distinguished the signals from choline (3.55 ppm), ethanolamine (3.15 ppm), phosphocholine (3.62 ppm), phosphoethanolamine (3.22 ppm, both were designated as Plp1) and peaks deriving from glycerophosphocholine (GPC) (3.68 ppm) and glycerophosphoethanolamine (GPE) (3.30 ppm, both were named as Plp2), known to be related to phospholipid biosynthesis and breakdown in vivo, respectively. The gene discussed is PLP2; the disease is neoplasm.