ACE and complex regional pain syndrome: It also prevents NFκB from binding to the promotor site for nitric oxide synthethase iNOS, thereby affecting the microcirculation in CRPS [53]; 6) For the NPY receptor, potential NFκB binding sites have been found in the promoter regions, suggesting a role for NFκB in the expressional regulation of this receptor [54]; 7) The important inflammatory modulator ACE reduces NFκB activity [55].