DAPK1 and neoplasm: The overall frequency of DAPK promoter methylation of 32.8% (40/122) found in the present study is in line with that reported by Toyooka's 37% (14/38) [44] and was not associated with tumor histology (p = 0.111, table 2), in agreement with Kim's study [21], or with tumor stage (p = 0.348, table 2).