CD4 and cancer: When efficiency of autologous T cell stimulation was compared between these two MDDC groups, there were no statistically significant differences between the antigen-specific (SEB, CMV-pp65, HER2/neu, and MAGE) CD4+ as well as CD8+ T cell proliferation induced by antigen-pulsed MDDC from these two groups (e.g. DC+SEB columns of healthy vs. cancer groups in Fig. 4C).