Addition of HNF-1α antisense ODN into the metanephric organ culture media also resulted in the formation of multiple cleft-like cysts (Figures 7a-E-F), while the number or size of the cyst formation were relatively more in the metanephroi with the treatment of HNF1-β antisense ODN (Figures 7a-G and H). Here, HNF1A is linked to cyst.