Collectrin knockout mice are lacking in the phenotype of diabetes, hypertension and renal cystic formation[3], [4]; however, it can be speculated that collectrin play a role in the pathophysiology of pancreatic β cells and collecting duct cells because many other genes, such as ACE2, may compensate the action of collectrin in the gene disruption studies. This evidence concerns the gene CLTRN and diabetes mellitus.