APOA1 and atherosclerosis: Due to the major differences in outcome of these studies and the lack of resemblance to the clinical setting in which patients with normal ApoA-I levels are treated with a systemically delivered ApoA-I or ApoA-IM mimetic compound, we wanted to elucidate the effects of wtApoA-I or ApoA-IM overexpression in a mouse model susceptible for atherosclerosis.