To demonstrate the regional specificity of mhtt-exon1 expression in the RosaHD/Dlx5/6-Cre (termed the striatal model), we performed immunostaining in 6 month old double transgenic mice with the EM48 antibody, a rabbit polyclonal antibody raised against the N-terminal of human htt which is highly specific to the aggregated forms of mhtt in HD patients and HD mouse brains [9]. The gene discussed is HTT; the disease is Huntington disease.