G6PC1 and Hyperglycemia: In parallel with the increase in PPARGC1a, microarray analysis revealed increased mRNA levels of the progluconeogenic genes phosphoenolpyruvate carboxykinase 1 (Pepck1) and glucose-6-phosphatase (G6pc) in the livers of POKO mice when compared to those of ob/ob mice (Table S2), suggesting hepatic gluconeogenesis may contribute to the hyperglycaemia observed in POKO mice.