Dent’s disease is now an accepted name for a group of hereditary tubular disorders, including X-linked recessive nephrolithiasis with renal failure, X-linked recessive hypophosphatemic rickets, and idiopathic low-molecular-weight proteinuria associated with hypercalciuric nephrocalcinosis resulting from mutations in the CLCN5 gene located on Xp11.22 encoding for the chloride channel 5 (CLC-5) [31, 32]. This evidence concerns the gene CLCN5 and Renal insufficiency.