Thus, for example, SULF1 is upregulated in significant subsets of breast cancer [38], pancreatic cancer [31], [39] (Table 1) lung adenocarcinoma [40] and hepatocellular carcinoma [30], while SULF2 is upregulated in multiple myeloma [32], breast cancer and CNS cancers [41]. Here, SULF1 is linked to central nervous system cancer.