VCAN and neoplasm: Versican, a large multi-domain chondroitin sulfate (CS) proteoglycan, is a major component of the ECM involved in cell adhesion, migration, proliferation and differentiation, all processes vital to tumour development and progression (Landolt et al, 1995; Zhang et al, 1998; Ang et al, 1999; Cattaruzza et al, 2004).