An interesting finding was that the majority of prostate cancers were unmethylated around a methylation hotspot (corresponding to the p-53, AP-2 and Sp-1/Sp3 binding sites), reported in both non-small cell lung carcinoma (61%) and hepatocellular carcinoma (33%) (Chang et al, 2002; Hanafusa et al, 2002). The gene discussed is SP1; the disease is Familial prostate cancer.