Overexpression of IGFBP3 has dramatic growth-inhibitory and proapoptotic effects in murine prostate tumours and prostate cancer cell lines (Modric et al, 2001; Devi et al, 2002), indicating that IGFBP3 may act as a tumour suppressor in prostate cells. This evidence concerns the gene IGFBP3 and prostate neoplasm.