Detailed studies in HEK293 cells showed that overexpression of LEDGF/p75 protected against daunorubicin-induced death to a similar extent as bcl-2 (Figs. 3, 4), suggesting that increased LEDGF/p75 might enhance chemotherapy resistance also in non-AML cells. The gene discussed is PSIP1; the disease is acute myeloid leukemia.