For TNF, carrying at least one copy of the TNF-308A allele was associated with increased asthma risk [relative risk (RR) = 1.54; 95% confidence interval (CI), 1.04–2.28; p = 0.031; false discovery rate = 0.12] relative to homozygotes for the major G allele (Table 3). Here, TNF is linked to asthma.