JAG1 and neoplasm: In this study, the use of whole apoptotic/necrotic tumor cells to load DCs exploits both the advantage of maturation signals delivered by necrotic cells as proposed by Gallucci et al [31] and the optimal Ag processing and presentation in HLA class I and class II molecules by DCs [32] of a vast repertoire of known as well as yet unknown Ags from apoptotic cells for the induction of anti-tumor immune responses.