CD4 and AIDS: The authors observed an increased relative rate of CD4+ T cell percent loss for those carrying KIR3DS1. In contrast to results by Martin et al., Gaudieri et al. did not find a significant protective effect against CD4+ T cell loss among Bw4Ile80/KIR3DS1 carriers, and in fact found these persons were at increased hazard (relative hazard of 14) for reaching AIDS (under the 1987 US Centers for Disease Control and Prevention definition).