DTNBP1 and schizophrenia: DTNBP1 could also influence schizophrenia liability and cognition by modulating glutamatergic or dopaminergic neurotransmission: DTNBP1 is located in presynaptic glutamatergic neurons and is reduced in patients with schizophrenia [29]; furthermore, down-regulation of DTNBP1 may lead to hyperactivation of midbrain dopaminergic systems [30].