DTNBP1 and schizophrenia: Not only is the 6p22–24 locus implicated in cognition and neurocognitive deficit in schizophrenia by recent genome scans [26,27] and has DTNBP1 been associated with more severe negative symptoms which are highly correlated to cognitive dysfunction [34,45], but also recent neuropathological studies have revealed reduced expression of DTNBP1 in the prefrontal cortex [28] and in the hippocampus [29] in postmortem brain tissue of schizophrenia patients.