There is growing evidence that genetic variation modulates cognition in schizophrenia; not only has genetic variation in DTNBP1 previously been associated with spatial working memory function and general intellectual function [32,33], but also variations in the DISC 1 gene have been related to structure and function of the hippocampus [57], and a functional variant in the NRG1 gene has been associated with impaired prefrontal function and decreased IQ [58]. The gene discussed is NRG1; the disease is schizophrenia.