CNR1 and Anxiety: In line with the effects of CB1 blockade, cannabinoid agonists (Δ9-tetrahydrocannabinol, WIN-55,212, and CP 55 940) decreased anxiety in mice (Berrendero & Maldonado, 2002; Valjent et al., 2002; Haller et al., 2004b; Patel & Hillard, 2006).