CB1 knockouts as well as wild-type mice treated with AM-251 showed anxiety in various tests, whereas cannabinoid agonists decreased anxiety (Berrendero & Maldonado, 2002; Haller et al., 2002, 2004a, 2004b; Maccarrone et al., 2002; Martin et al., 2002; Valjent et al., 2002; Uriguen et al., 2004; Rodgers et al., 2005; Patel & Hillard, 2006). Here, CNR1 is linked to Anxiety.