In contrast to mice, nonsedative doses of CB1 agonists (AM-411, CP-55,940 and HU-210) increased anxiety in the elevated plus-maze, social interaction, open field and defensive withdrawal tests in Wistar, Sprague–Dawley, hooded Lister and Long–Evans rats (Rodriguez de Fonseca et al., 1996; Giuliani et al., 2000; Arevalo et al., 2001; Marin et al., 2003; Genn et al., 2004; Hill & Gorzalka, 2004; Marco et al., 2004; McLaughlin et al., 2005). Here, CNR1 is linked to Anxiety.