However, this work is preliminary and we acknowledge that this inhibitor is unlikely to act as a single therapy to overcome EGFR signaling in glioblastomas because 1) drug resistance is a frequent problem with single modality therapy, 2) the EGFR pathway can be activated at a point downstream of EGFR in glioblastoma, and 3) glioblastoma cell lines and xenografts thrive after loss of EGFRvIII. Here, EGFR is linked to glioblastoma.