Aberrant E-cadherin expression (heterogeneous, cytoplasmic, or absent) has been detected immunohistochemically in several cancers, including head and neck carcinoma, gastric adenocarcinoma, lobular breast carcinoma, lung cancer, colorectal carcinoma, prostate adenocarcinoma, pancreatic, and bladder cancer (Becker et al, 1994; Hirohashi, 1998; Chang et al, 2002; Charalabopoulos et al, 2002, 2004; Hirohashi and Kanai, 2003; Mastracci et al, 2005; Massarelli et al, 2005). The gene discussed is CDH1; the disease is breast lobular carcinoma.