CDH1 and neoplasm: Furthermore, there are contradictory data on the possible association between E-cadherin expression and high-grade tumours with increased metastatic potential (Oka et al, 1993; Charpin et al, 1997; Heimann et al, 2000; Gillett et al, 2001; Parker et al, 2001; Elzagheid et al, 2002; Gupta et al, 2003; Knudsen and Wheelock, 2005; Rakha et al, 2005).