In approximately 50% of lobular carcinomas loss of E-cadherin involves LOH at the chromosomal region of 16q, which includes the E-cadherin gene CDH1 locus and mutations in the remaining allele (Kanai et al, 1994; Vos et al, 1997; Huiping et al, 1999; Knudsen and Wheelock, 2005; Mastracci et al, 2005). This evidence concerns the gene CDH1 and breast lobular carcinoma.