APOE and aortic atherosclerosis: Consistently, hyperlipidemic rabbits exposed to PM10 (particulate matter ≤ 10 μm in aerodynamic diameter) or ApoE−/− mice exposed to PM2.5 (≤ 2.5 μm ) develop advanced coronary and/or aortic atherosclerosis (Chen and Nadziejko 2005; Sun et al. 2005).