GHR and obesity due to melanocortin 4 receptor deficiency: Another interesting category at the top of the list is 'Neuroactive ligand receptor interaction', which includes Leptin, GHR and NR3C1. Leptin and growth hormone receptor (GHR) are known in the literature to be associated with obesity and a high-fat diet in several tissues [17]; nuclear receptor subfamily 3, group C, member 1 (NR3C1) is a ligand-activated transcription factor that interacts with high affinity with cortisol and other glucocorticoids.